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2014 ; 20
(20
): 5866-73
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Nucleic acid based logical systems
#MMPMID24692306
Han D
; Kang H
; Zhang T
; Wu C
; Zhou C
; You M
; Chen Z
; Zhang X
; Tan W
Chemistry
2014[May]; 20
(20
): 5866-73
PMID24692306
show ga
Researchers increasingly visualize a significant role for artificial biochemical
logical systems in biological engineering, much like digital logic circuits in
electrical engineering. Those logical systems could be utilized as a type of
servomechanism to control nanodevices in vitro, monitor chemical reactions in
situ, or regulate gene expression in vivo. Nucleic acids (NA), as carriers of
genetic information with well-regulated and predictable structures, are promising
materials for the design and engineering of biochemical circuits. A number of
logical devices based on nucleic acids (NA) have been designed to handle various
processes for technological or biotechnological purposes. This article focuses on
the most recent and important developments in NA-based logical devices and their
evolution from in vitro, through cellular, even towards in vivo biological
applications.
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