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10.1002/cmdc.201700266

http://scihub22266oqcxt.onion/10.1002/cmdc.201700266
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suck abstract from ncbi


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pmid28480997
      ChemMedChem 2017 ; 12 (12 ): 872-882
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  • Nucleic Acid Templated Reactions for Chemical Biology #MMPMID28480997
  • Di Pisa M ; Seitz O
  • ChemMedChem 2017[Jun]; 12 (12 ): 872-882 PMID28480997 show ga
  • Nucleic acid directed bioorthogonal reactions offer the fascinating opportunity to unveil and redirect a plethora of intracellular mechanisms. Nano- to picomolar amounts of specific RNA molecules serve as templates and catalyze the selective formation of molecules that 1)?exert biological effects, or 2)?provide measurable signals for RNA detection. Turnover of reactants on the template is a valuable asset when concentrations of RNA templates are low. The idea is to use RNA-templated reactions to fully control the biodistribution of drugs and to push the detection limits of DNA or RNA analytes to extraordinary sensitivities. Herein we review recent and instructive examples of conditional synthesis or release of compounds for in?cellulo protein interference and intracellular nucleic acid imaging.
  • |*DNA/analysis/genetics/metabolism [MESH]
  • |*RNA/analysis/genetics/metabolism [MESH]
  • |Molecular Structure [MESH]
  • |Pharmaceutical Preparations/*chemistry/*metabolism [MESH]


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