Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24530809
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Curr+Opin+Cell+Biol
2014 ; 28
(ä): 28-35
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Nuclear trafficking in health and disease
#MMPMID24530809
Mor A
; White MA
; Fontoura BM
Curr Opin Cell Biol
2014[Jun]; 28
(ä): 28-35
PMID24530809
show ga
In eukaryotic cells, the cytoplasm and the nucleus are separated by a
double-membraned nuclear envelope (NE). Thus, transport of molecules between the
nucleus and the cytoplasm occurs via gateways termed the nuclear pore complexes
(NPCs), which are the largest intracellular channels in nature. While small
molecules can passively translocate through the NPC, large molecules are actively
imported into the nucleus by interacting with receptors that bind nuclear pore
complex proteins (Nups). Regulatory factors then function in assembly and
disassembly of transport complexes. Signaling pathways, cell cycle, pathogens,
and other physiopathological conditions regulate various constituents of the
nuclear transport machinery. Here, we will discuss several findings related to
modulation of nuclear transport during physiological and pathological conditions,
including tumorigenesis, viral infection, and congenital syndrome. We will also
explore chemical biological approaches that are being used as probes to reveal
new mechanisms that regulate nucleocytoplasmic trafficking and that are serving
as starting points for drug development.
free
free
free
