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2017 ; 6
(ä): 8
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Nuclear roles for cilia-associated proteins
#MMPMID28560031
McClure-Begley TD
; Klymkowsky MW
Cilia
2017[]; 6
(ä): 8
PMID28560031
show ga
Cilia appear to be derived, evolutionarily, from structures present in the
ancestral (pre-ciliary) eukaryote, such as microtubule-based vesicle trafficking
and chromosome segregation systems. Experimental observations suggest that the
ciliary gate, the molecular complex that mediates the selective molecular
movement between cytoplasmic and ciliary compartments, shares features with
nuclear pores. Our hypothesis is that this shared transport machinery is at least
partially responsible for the observation that a number of ciliary and
ciliogenesis-associated proteins are found within nuclei where they play roles in
the regulation of gene expression, DNA repair, and nuclear import and export.
Recognizing the potential for such nuclear roles is critical when considering the
phenotypic effects that arise from the mutational modification of ciliary
proteins.