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2018 ; 9
(1
): 142-148
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Nuclear pore complexes as hubs for gene regulation
#MMPMID29095096
D'Angelo MA
Nucleus
2018[Jan]; 9
(1
): 142-148
PMID29095096
show ga
Nuclear pore complexes (NPCs), the channels connecting the nucleus with the
cytoplasm, are the largest protein structures of the nuclear envelope. In
addition to their role in regulating nucleocytoplasmic transport, increasing
evidence shows that these multiprotein structures play central roles in the
regulation of gene activity. In light of recent discoveries, NPCs are emerging as
scaffolds that mediate the regulation of specific gene sets at the nuclear
periphery. The function of NPCs as genome organizers and hubs for transcriptional
regulation provides additional evidence that the compartmentalization of genes
and transcriptional regulators within the nuclear space is an important mechanism
of gene expression regulation.