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10.1007/s12195-016-0437-8 http://scihub22266oqcxt.onion/10.1007/s12195-016-0437-8 C4999255!4999255 !27570565     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27570565 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27570565 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Mol+Bioeng 2016 ; 9 (2 ): 258-267 Nephropedia Template TP {{tp|p=27570565 |t=2016. Nuclear lamins in cancer |pdf=|usr=}}{{27570565 }} gab.com Text Nuclear lamins in cancer JO: Cell Mol Bioeng http://www.kidney.de/pget.php?&tw=1&pmid=27570565 #FOAvip Dysmorphic nuclei are commonly seen in cancers and provide strong motivation for studying the main structural proteins of nuclei, the lamins, in cancer. Past studies have also demonstrated the significance of microenvironment mechanics to cancer progression, which is extremely interesting because the lamina was recently shown to be mechanosensitive. Here, we review current knowledge relating cancer progression to lamina biophysics. Lamin levels can constrain cancer cell migration in 3D and thereby impede tumor growth, and lamins can also protect a cancer cell's genome. In addition, lamins can influence transcriptional regulators (RAR, SRF, YAP/TAZ) and chromosome conformation in lamina associated domains. Further investigation of the roles for lamins in cancer and even DNA damage may lead to new therapies or at least to a clearer understanding of lamins as bio-markers in cancer progression. Twit Text FOAVip Nuclear lamins in cancer ????Cell Mol Bioeng http://www.kidney.de/pget.php?&tw=1&pmid=27570565 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27570565 #FOAvip English Wikipedia <ref>{{Cite pmid|27570565 }}</ref> Nuclear lamins in cancer #MMPMID27570565 Irianto J ; Pfeifer CR ; Ivanovska IL ; Swift J ; Discher DE Cell Mol Bioeng 2016[Jun]; 9 (2 ): 258-267 PMID27570565 show ga Dysmorphic nuclei are commonly seen in cancers and provide strong motivation for studying the main structural proteins of nuclei, the lamins, in cancer. Past studies have also demonstrated the significance of microenvironment mechanics to cancer progression, which is extremely interesting because the lamina was recently shown to be mechanosensitive. Here, we review current knowledge relating cancer progression to lamina biophysics. Lamin levels can constrain cancer cell migration in 3D and thereby impede tumor growth, and lamins can also protect a cancer cell's genome. In addition, lamins can influence transcriptional regulators (RAR, SRF, YAP/TAZ) and chromosome conformation in lamina associated domains. Further investigation of the roles for lamins in cancer and even DNA damage may lead to new therapies or at least to a clearer understanding of lamins as bio-markers in cancer progression. äNuclear lamins in cancer (epmc).pdf DeepDyve Pubget Overpricing