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2015 ; 6
(2
): 114-7
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Nuclear envelope regulates the circadian clock
#MMPMID25746393
Zhang L
; Ptá?k LJ
; Fu YH
Nucleus
2015[]; 6
(2
): 114-7
PMID25746393
show ga
Daily rhythms of behavior and physiology arise from endogenous circadian clocks.
At the molecular level, the circadian clock consists of intricate transcriptional
and post-transcriptional feedback loops that drive 24h rhythms in a vast
repertoire of basic cellular processes. The nuclear envelope, as a fundamental
component of the cell, has been shown to function as a global transcriptional
regulatory machinery. Recently we found that nuclear envelope proteins regulate
the circadian clock both in the mammalian system and in fruit flies. One of these
proteins, MAN1, impinges on the clock by binding to the promoter region of the
core clock gene BMAL1 and enhances its transcription. Here we discuss about other
potential mechanisms employed by nuclear envelope proteins to regulate the
circadian clock and possible biological relevance of these modulations.