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2016 ; 63
(1
): 7-20
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Nuclear Noncoding RNAs and Genome Stability
#MMPMID27392145
Khanduja JS
; Calvo IA
; Joh RI
; Hill IT
; Motamedi M
Mol Cell
2016[Jul]; 63
(1
): 7-20
PMID27392145
show ga
In modern molecular biology, RNA has emerged as a versatile macromolecule capable
of mediating an astonishing number of biological functions beyond its role as a
transient messenger of genetic information. The recent discovery and functional
analyses of new classes of noncoding RNAs (ncRNAs) have revealed their widespread
use in many pathways, including several in the nucleus. This Review focuses on
the mechanisms by which nuclear ncRNAs directly contribute to the maintenance of
genome stability. We discuss how ncRNAs inhibit spurious recombination among
repetitive DNA elements, repress mobilization of transposable elements (TEs),
template or bridge DNA double-strand breaks (DSBs) during repair, and direct
developmentally regulated genome rearrangements in some ciliates. These studies
reveal an unexpected repertoire of mechanisms by which ncRNAs contribute to
genome stability and even potentially fuel evolution by acting as templates for
genome modification.
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