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2018 ; 2018
(ä): 9304091
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Nrf2-Mediated Metabolic Reprogramming in Cancer
#MMPMID29670683
Wang YY
; Chen J
; Liu XM
; Zhao R
; Zhe H
Oxid Med Cell Longev
2018[]; 2018
(ä): 9304091
PMID29670683
show ga
Metabolic reprogramming is one of the hallmarks of cancer. Nrf2 pathway is one of
the critical signaling cascades involved in cell defense and survival against
oxidative stress. The significance of Nrf2 in cancer metabolism begins to be
recognized. In this minireview, we focus on the Nrf2-mediated cancer metabolic
reprogramming and intend to highlight the role of Nrf2 in the regulation of
malignant transformation, cancer proliferation, and the development of treatment
resistance via metabolic adaptations. We hope for the development of noninvasive
biomarkers and novel therapeutic approaches for cancer based on Nrf2-directed
cancer metabolic reprogramming in the near future.