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10.1155/2018/9304091

http://scihub22266oqcxt.onion/10.1155/2018/9304091
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suck abstract from ncbi


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pmid29670683
      Oxid+Med+Cell+Longev 2018 ; 2018 (ä): 9304091
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  • Nrf2-Mediated Metabolic Reprogramming in Cancer #MMPMID29670683
  • Wang YY ; Chen J ; Liu XM ; Zhao R ; Zhe H
  • Oxid Med Cell Longev 2018[]; 2018 (ä): 9304091 PMID29670683 show ga
  • Metabolic reprogramming is one of the hallmarks of cancer. Nrf2 pathway is one of the critical signaling cascades involved in cell defense and survival against oxidative stress. The significance of Nrf2 in cancer metabolism begins to be recognized. In this minireview, we focus on the Nrf2-mediated cancer metabolic reprogramming and intend to highlight the role of Nrf2 in the regulation of malignant transformation, cancer proliferation, and the development of treatment resistance via metabolic adaptations. We hope for the development of noninvasive biomarkers and novel therapeutic approaches for cancer based on Nrf2-directed cancer metabolic reprogramming in the near future.
  • |Animals [MESH]
  • |Cell Transformation, Neoplastic [MESH]
  • |Drug Resistance, Neoplasm [MESH]
  • |Humans [MESH]
  • |NF-E2-Related Factor 2/*metabolism [MESH]
  • |Neoplasms/*metabolism/pathology [MESH]


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