Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25975985
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Free+Radic+Biol+Med
2015 ; 88
(Pt B
): 268-274
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Nrf2 promotes survival following exposure to ionizing radiation
#MMPMID25975985
Sekhar KR
; Freeman ML
Free Radic Biol Med
2015[Nov]; 88
(Pt B
): 268-274
PMID25975985
show ga
Nrf2 is a transcription factor that promotes antioxidant and drug-metabolizing
gene expression. It also regulates the transcription of genes involved in
carbohydrate and lipid metabolism, NADPH regeneration, and heme and iron
metabolism, as well as proteasome metabolism. Emerging research has identified
Nrf2 as a critical factor for promoting survival of mammalian cells subjected to
ionizing radiation. At a mechanistic level, Nrf2 promotes the repair of DNA
damage and drives detoxification of superoxide that is generated hours to days
after irradiation. This review summarizes research in these areas and discusses
targeting of Nrf2 in radiation-resistant cancer and Nrf2?s role in mitigating
acute radiation syndrome.