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10.1111/ajt.13368

http://scihub22266oqcxt.onion/10.1111/ajt.13368
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suck abstract from ncbi


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pmid26104383
      Am+J+Transplant 2015 ; 15 (11 ): 2888-99
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  • Nox2 is a mediator of ischemia reperfusion injury #MMPMID26104383
  • Karim AS ; Reese SR ; Wilson NA ; Jacobson LM ; Zhong W ; Djamali A
  • Am J Transplant 2015[Nov]; 15 (11 ): 2888-99 PMID26104383 show ga
  • Delayed graft function (DGF) results from ischemia-reperfusion injury (IRI) and the generation of reactive oxygen species. We hypothesized that NADPH oxidase 2 (Nox2) plays an important role in pathways leading to DGF. We tested this hypothesis in vitro, in an animal model of IRI using wild type and Nox2(-/-) mice, and in patients with DGF. Under hypoxic conditions, primary tubular epithelial cells from Nox2(-/-) mice had reduced expression of MMP2, vimentin, and HSP27. BUN and creatinine levels were significantly increased in both Nox2(-/-) and WT mice at 4 weeks and 6 months after IRI, suggesting the development of acute and chronic kidney injury. At 4 weeks, kidney fibrosis (?-SMA, picrosirius) and oxidative stress (dihydroethidine, HNE) were significantly reduced in Nox2(-/-) mice, confirming the oxidative and pro-fibrotic effects of Nox2. The molecular signature of IRI using genomic analyses demonstrated a significant decline in hypoxia reponse, oxidative stress, fibrosis, and inflammation in Nox2(-/-) mice. Immunohistochemical analyses of pre-implanatation kidney allograft biopsies from patients with subsequent DGF showed significantly greater Nox2 levels and vascular injury compared with patients without DGF. These studies demonstrate that Nox2 is a modulator of IRI and its absence is associated with reduced inflammation, OS, and fibrosis.
  • |Analysis of Variance [MESH]
  • |Animals [MESH]
  • |Biomarkers/metabolism [MESH]
  • |Case-Control Studies [MESH]
  • |Delayed Graft Function/*metabolism/pathology [MESH]
  • |Disease Models, Animal [MESH]
  • |Female [MESH]
  • |Fibrosis/pathology [MESH]
  • |Humans [MESH]
  • |Immunoblotting [MESH]
  • |Immunohistochemistry [MESH]
  • |Kidney Function Tests [MESH]
  • |Kidney Transplantation/*adverse effects [MESH]
  • |Male [MESH]
  • |Membrane Glycoproteins/*metabolism [MESH]
  • |Mice [MESH]
  • |Mice, Inbred C57BL [MESH]
  • |Mice, Knockout [MESH]
  • |NADPH Oxidase 2 [MESH]
  • |NADPH Oxidases/*metabolism [MESH]
  • |Nephrectomy/adverse effects/methods [MESH]
  • |Oxidative Stress/physiology [MESH]
  • |RNA, Small Interfering/*metabolism [MESH]
  • |Random Allocation [MESH]
  • |Reactive Oxygen Species/metabolism [MESH]
  • |Reperfusion Injury/*metabolism/pathology [MESH]


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