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2013 ; 19
(5
): 417-23
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Novelties in pharmacological management of cardiopulmonary resuscitation
#MMPMID23995130
Bartos JA
; Yannopoulos D
Curr Opin Crit Care
2013[Oct]; 19
(5
): 417-23
PMID23995130
show ga
PURPOSE OF REVIEW: The ultimate goal of cardiopulmonary resuscitation is
long-term neurologically intact survival. Despite numerous well-designed studies,
the medications currently used in advanced cardiac life support have not
demonstrated success in this regard. This review describes the novel therapeutics
under investigation to improve functional recovery and survival. RECENT FINDINGS:
Whereas current medications focus on achieving return of spontaneous circulation
and improved hemodynamics, novel therapies currently in development are focused
on improving cellular survival and function by preventing metabolic derangement,
protecting mitochondria, and preventing cell death caused by cardiac arrest.
Improved cardiac and neurologic function and survival benefits have been observed
using animal models of cardiopulmonary arrest. SUMMARY: Although substantial data
have shown benefits using robust animal models, further human studies are
necessary to investigate the potential long-term benefits of these therapies.
|Adrenergic beta-Antagonists/therapeutic use
[MESH]
free
free
free
