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2014 ; 28
(ä): 58-63
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Novel vaccine approaches for protection against intracellular pathogens
#MMPMID24608070
Griffiths KL
; Khader SA
Curr Opin Immunol
2014[Jun]; 28
(ä): 58-63
PMID24608070
show ga
Vaccination against intracellular pathogens requires generation of a pool of
memory T cells able to respond upon infection and mediate either killing of the
infected cell or induce killing mechanisms in the infected cell. T cell-inducing
vaccines must aim to target the antigen to antigen-presenting cells (APCs) so
that it can be presented on MHC molecules on the cell surface. Methods to do this
include making use of vectors such as plasmid DNA or viruses, live attenuated
pathogens or subunit vaccines targeted and enhanced using adjuvants. The choice
of approach should be guided by the phenotype and localization of the desired T
cell response. This review will discuss current approaches in the pipeline for
the development of T cell-inducing vaccines, including vectored, live attenuated,
and subunit vaccines.