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10.1093/femspd/ftv074 http://scihub22266oqcxt.onion/10.1093/femspd/ftv074 C4626598!4626598 !26394802     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26394802 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26394802 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Pathog+Dis 2015 ; 73 (8 ): ftv074 Nephropedia Template TP {{tp|p=26394802 |t=2015. Novel therapies for the treatment of pertussis disease |pdf=|usr=}}{{26394802 }} gab.com Text Novel therapies for the treatment of pertussis disease JO: Pathog Dis http://www.kidney.de/pget.php?&tw=1&pmid=26394802 #FOAvip Whooping cough, or pertussis, incidence has reached levels not seen since the 1950s. Previous studies have shown that antibiotics fail to improve the course of disease unless diagnosed early. Early diagnosis is complicated by the non-diagnostic presentation of disease early in infection. This review focuses on previous attempts at developing novel host-directed therapies for the treatment of pertussis. In addition, two novel approaches from our group are discussed. Manipulation of the signaling pathway of sphingosine-1-phosphate, a lipid involved in many immune processes, has shown great promise, but is in its infancy. Pendrin, a host epithelial anion exchanger upregulated in the airways with B. pertussis infection, appears to drive mucus production and dysregulation of airway surface liquid pH and salinity. In addition to detailing these potential new therapeutic targets, the need for greater focus on the neonatal model of disease is highlighted. Twit Text FOAVip Novel therapies for the treatment of pertussis disease ????Pathog Dis http://www.kidney.de/pget.php?&tw=1&pmid=26394802 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26394802 #FOAvip English Wikipedia <ref>{{Cite pmid|26394802 }}</ref> Novel therapies for the treatment of pertussis disease #MMPMID26394802 Scanlon KM ; Skerry C ; Carbonetti NH Pathog Dis 2015[Nov]; 73 (8 ): ftv074 PMID26394802 show ga Whooping cough, or pertussis, incidence has reached levels not seen since the 1950s. Previous studies have shown that antibiotics fail to improve the course of disease unless diagnosed early. Early diagnosis is complicated by the non-diagnostic presentation of disease early in infection. This review focuses on previous attempts at developing novel host-directed therapies for the treatment of pertussis. In addition, two novel approaches from our group are discussed. Manipulation of the signaling pathway of sphingosine-1-phosphate, a lipid involved in many immune processes, has shown great promise, but is in its infancy. Pendrin, a host epithelial anion exchanger upregulated in the airways with B. pertussis infection, appears to drive mucus production and dysregulation of airway surface liquid pH and salinity. In addition to detailing these potential new therapeutic targets, the need for greater focus on the neonatal model of disease is highlighted. |Animals [MESH] |Drug Discovery/trends [MESH] |Drug Therapy/*methods [MESH] |Enzyme Inhibitors/metabolism [MESH] |Humans [MESH] |Immunologic Factors/metabolism [MESH] |Immunotherapy/*methods [MESH] |Lysophospholipids/metabolism [MESH] |Membrane Transport Proteins/metabolism [MESH] |Sphingosine/analogs & derivatives/metabolism [MESH] |Sulfate Transporters [MESH]Novel therapies for the treatment of pertussis disease (epmc).pdf DeepDyve Pubget Overpricing