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10.1111/cei.12602 http://scihub22266oqcxt.onion/10.1111/cei.12602 C4449764!4449764 !25682849     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25682849 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25682849 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Clin+Exp+Immunol 2015 ; 180 (3 ): 353-60 Nephropedia Template TP {{tp|p=25682849 |t=2015. Novel therapies for memory cells in autoimmune diseases |pdf=|usr=}}{{25682849 }} gab.com Text Novel therapies for memory cells in autoimmune diseases JO: Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25682849 #FOAvip Autoimmune diseases are a major cause of morbidity, and their incidence and prevalence continue to rise. Treatments for these diseases are non-specific and result in significant adverse effects. Targeted therapies may help in improving the risk : benefit ratio associated with treatment. Immunological memory is an important feature of the vertebrate immune system that results in the production of cells that are long-lived and able to respond to antigens in a more robust manner. In the setting of autoimmunity this characteristic becomes detrimental due to the ongoing response to a self-antigen(s). These memory cells have been shown to play key roles in various autoimmune diseases such as type 1 diabetes, multiple sclerosis and psoriasis. Memory T cells and B cells can be identified based on various molecules expressed on their surface. Memory T cells can be divided into three main categories - central memory, effector memory and resident memory cells. These subsets have different proliferative potential and cytokine-producing abilities. Utilizing differentially expressed surface molecules or downstream signalling pathway proteins in these cells it is now possible to target memory cells while sparing naive cells. We will discuss the various available options for such a strategy and several potential strategies that may yield successful therapies in the future. Twit Text FOAVip Novel therapies for memory cells in autoimmune diseases ????Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25682849 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25682849 #FOAvip English Wikipedia <ref>{{Cite pmid|25682849 }}</ref> Novel therapies for memory cells in autoimmune diseases #MMPMID25682849 Bhargava P ; Calabresi PA Clin Exp Immunol 2015[Jun]; 180 (3 ): 353-60 PMID25682849 show ga Autoimmune diseases are a major cause of morbidity, and their incidence and prevalence continue to rise. Treatments for these diseases are non-specific and result in significant adverse effects. Targeted therapies may help in improving the risk : benefit ratio associated with treatment. Immunological memory is an important feature of the vertebrate immune system that results in the production of cells that are long-lived and able to respond to antigens in a more robust manner. In the setting of autoimmunity this characteristic becomes detrimental due to the ongoing response to a self-antigen(s). These memory cells have been shown to play key roles in various autoimmune diseases such as type 1 diabetes, multiple sclerosis and psoriasis. Memory T cells and B cells can be identified based on various molecules expressed on their surface. Memory T cells can be divided into three main categories - central memory, effector memory and resident memory cells. These subsets have different proliferative potential and cytokine-producing abilities. Utilizing differentially expressed surface molecules or downstream signalling pathway proteins in these cells it is now possible to target memory cells while sparing naive cells. We will discuss the various available options for such a strategy and several potential strategies that may yield successful therapies in the future. |Animals [MESH] |Autoimmune Diseases/*immunology/metabolism/*therapy [MESH] |B-Lymphocytes/immunology/metabolism [MESH] |Cell Survival/immunology [MESH] |Cytokines/biosynthesis [MESH] |Humans [MESH] |Immunologic Memory/*drug effects [MESH] |Immunotherapy [MESH] |Molecular Targeted Therapy [MESH] |T-Lymphocyte Subsets/*drug effects/*immunology/metabolism [MESH]Novel therapies for memory cells in autoimmune diseases (epmc).pdf DeepDyve Pubget Overpricing