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2015 ; 21
(2
): 62-9
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Novel therapeutic targets of tumor metabolism
#MMPMID25815845
Kishton RJ
; Rathmell JC
Cancer J
2015[Mar]; 21
(2
): 62-9
PMID25815845
show ga
The study of tumor metabolism has resulted in new understandings of how cancer
cells modify metabolic pathways that control cellular energetics to allow
increased proliferation and survival. Tumor cells have been shown to alter
metabolic pathways involved in glucose, glutamine, and mitochondrial metabolism
to generate raw materials needed for rapid cellular proliferation, maintain
favorable cellular redox environments, modify cellular epigenetics, and even
promote and maintain oncogenic transformation. As a consequence, there has been
intense scientific and clinical interest in targeting metabolic alterations that
are commonly adopted by tumor cells for therapeutic purposes. In this review, we
describe common metabolic alterations seen in tumor cells and discuss how these
alterations are being investigated as potential targets for pharmacological
intervention in preclinical and clinical settings. We also discuss some of the
challenges associated with using tumor metabolism as a therapeutic target in
cancer therapy, along with potential avenues to overcome these challenges.
|*Molecular Targeted Therapy
[MESH]
|Animals
[MESH]
|Antimetabolites, Antineoplastic/*pharmacology/*therapeutic use
[MESH]
|Antineoplastic Combined Chemotherapy Protocols/therapeutic use
[MESH]
free
free
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