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10.1080/15257770.2024.2341406

http://scihub22266oqcxt.onion/10.1080/15257770.2024.2341406
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suck abstract from ncbi


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pmid38753464      Nucleosides+Nucleotides+Nucleic+Acids 2024 ; ä (ä): 1-18
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  • Novel synthesis of the first new class of triazine sulfonamide thioglycosides and the evaluation of their anti-tumor and anti-viral activities against human coronavirus #MMPMID38753464
  • Mohamed-Ezzat RA; Elgemeie GH
  • Nucleosides Nucleotides Nucleic Acids 2024[May]; ä (ä): 1-18 PMID38753464show ga
  • Novel class of triazine sulfonamide thioglycosides was designed and synthesized. Those novel structures comprising three essential and pharmacological significant moieties such as the triazine, sulfonamide, and thioglycosidic scaffolds. The triazine sulfonamides were furnished via a direct approach starting from potassium cyanocarbonimidodithioate, then the corresponding triazine sulfonamide thioglycosides were generated using the peracylated alpha-d-gluco- and galacto-pyranosyl bromides. Anti-viral evaluation of compounds in vitro against HCoV-229E virus revealed that some compounds possess promising activity. Compounds 4a, 4b, 4d, 6d and 6e indicate from moderate to low antiviral activity against low pathogenic coronavirus 229E in comparison with remdesivir at a concentration of 100 microg/mL. Additionally their in vitro anti-proliferative effects against NCI 60 cancer cell lines cell lines were also investigated. Compound 4a, the most potent compound among the estimated compounds, revealed remarkably lowest cell growth promotion against CNS cancer SNB-75, and renal cancer UO-31.
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