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2016 ; 2
(3
): 134-143
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Novel mechanisms of regulation of miRNAs in CLL
#MMPMID27213184
Balatti V
; Acunzo M
; Pekarky Y
; Croce CM
Trends Cancer
2016[Mar]; 2
(3
): 134-143
PMID27213184
show ga
B-cell chronic lymphocytic leukemia (CLL) is the most common adult human
leukemia. Although, the molecular alterations leading to CLL onset and
progression are still under investigation (specifically, the interplay and exact
role of oncogenes and tumor suppressors in CLL pathogenesis). MicroRNAs are small
non-coding RNAs that regulate gene expression and are expressed in a tissue
specific manner. Deregulation of microRNAs can alter expression levels of genes
involved in the development and/or progression of tumors. In CLL, microRNAs can
function as oncogenes or tumor suppressors. Here, we review the most recent
findings on the role of microRNAs in the onset/progression of CLL, and how this
knowledge can be used to identify new biomarkers and targets to treat this
leukemia.