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2014 ; 55
(10
): 1986-95
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Novel lysophosphoplipid receptors: their structure and function
#MMPMID24891334
Makide K
; Uwamizu A
; Shinjo Y
; Ishiguro J
; Okutani M
; Inoue A
; Aoki J
J Lipid Res
2014[Oct]; 55
(10
): 1986-95
PMID24891334
show ga
It is now accepted that lysophospholipids (LysoGPs) have a wide variety of
functions as lipid mediators that are exerted through G protein-coupled receptors
(GPCRs) specific to each lysophospholipid. While the roles of some LysoGPs, such
as lysophosphatidic acid and sphingosine 1-phosphate, have been thoroughly
examined, little is known about the roles of several other LysoGPs, such as
lysophosphatidylserine (LysoPS), lysophosphatidylthreonine,
lysophosphatidylethanolamine, lysophosphatidylinositol (LPI), and
lysophosphatidylglycerol. Recently, a GPCR was found for LPI (GPR55) and three
GPCRs (GPR34/LPS1, P2Y10/LPS2, and GPR174/LPS3) were found for LysoPS. In this
review, we focus on these newly identified GPCRs and summarize the actions of
LysoPS and LPI as lipid mediators.