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10.1038/aps.2015.73 http://scihub22266oqcxt.onion/10.1038/aps.2015.73 C4648174!4648174 !26364800     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26364800 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26364800 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Acta+Pharmacol+Sin 2015 ; 36 (10 ): 1177-90 Nephropedia Template TP {{tp|p=26364800 |t=2015. Novel endogenous angiogenesis inhibitors and their therapeutic potential |pdf=|usr=}}{{26364800 }} gab.com Text Novel endogenous angiogenesis inhibitors and their therapeutic potential JO: Acta Pharmacol Sin http://www.kidney.de/pget.php?&tw=1&pmid=26364800 #FOAvip Angiogenesis, the formation of new blood vessels from the pre-existing vasculature is essential for embryonic development and tissue homeostasis. It also plays critical roles in diseases such as cancer and retinopathy. A delicate balance between pro- and anti-angiogenic factors ensures normal physiological homeostasis. Endogenous angiogenesis inhibitors are proteins or protein fragments that are formed in the body and have the ability to limit angiogenesis. Many endogenous angiogenesis inhibitors have been discovered, and the list continues to grow. Endogenous protein/peptide inhibitors are relatively less toxic, better tolerated and have a lower risk of drug resistance, which makes them attractive as drug candidates. In this review, we highlight ten novel endogenous protein angiogenesis inhibitors discovered within the last five years, including ISM1, FKBPL, CHIP, ARHGAP18, MMRN2, SOCS3, TAp73, ZNF24, GPR56 and JWA. Although some of these proteins have been well characterized for other biological functions, we focus on their new and specific roles in angiogenesis inhibition and discuss their potential for therapeutic application. Twit Text FOAVip Novel endogenous angiogenesis inhibitors and their therapeutic potential ????Acta Pharmacol Sin http://www.kidney.de/pget.php?&tw=1&pmid=26364800 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26364800 #FOAvip English Wikipedia <ref>{{Cite pmid|26364800 }}</ref> Novel endogenous angiogenesis inhibitors and their therapeutic potential #MMPMID26364800 Rao N ; Lee YF ; Ge R Acta Pharmacol Sin 2015[Oct]; 36 (10 ): 1177-90 PMID26364800 show ga Angiogenesis, the formation of new blood vessels from the pre-existing vasculature is essential for embryonic development and tissue homeostasis. It also plays critical roles in diseases such as cancer and retinopathy. A delicate balance between pro- and anti-angiogenic factors ensures normal physiological homeostasis. Endogenous angiogenesis inhibitors are proteins or protein fragments that are formed in the body and have the ability to limit angiogenesis. Many endogenous angiogenesis inhibitors have been discovered, and the list continues to grow. Endogenous protein/peptide inhibitors are relatively less toxic, better tolerated and have a lower risk of drug resistance, which makes them attractive as drug candidates. In this review, we highlight ten novel endogenous protein angiogenesis inhibitors discovered within the last five years, including ISM1, FKBPL, CHIP, ARHGAP18, MMRN2, SOCS3, TAp73, ZNF24, GPR56 and JWA. Although some of these proteins have been well characterized for other biological functions, we focus on their new and specific roles in angiogenesis inhibition and discuss their potential for therapeutic application. |*Drug Discovery/methods [MESH] |Angiogenesis Inhibitors/metabolism/*pharmacology [MESH] |Animals [MESH] |Humans [MESH] |Neoplasms/blood supply/*drug therapy/metabolism/pathology [MESH] |Neovascularization, Pathologic/*drug therapy/metabolism/pathology [MESH]Novel endogenous angiogenesis inhibitors and their therapeutic potenti(epmc).pdf DeepDyve Pubget Overpricing