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10.1002/rth2.12115

http://scihub22266oqcxt.onion/10.1002/rth2.12115
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suck abstract from ncbi


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pmid30046748
      Res+Pract+Thromb+Haemost 2018 ; 2 (3 ): 439-449
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  • Novel aspects of antiplatelet therapy in cardiovascular disease #MMPMID30046748
  • Gremmel T ; Michelson AD ; Frelinger AL III ; Bhatt DL
  • Res Pract Thromb Haemost 2018[Jul]; 2 (3 ): 439-449 PMID30046748 show ga
  • Antiplatelet therapy is a cornerstone in the secondary prophylaxis of adverse cardiovascular events such as myocardial infarction and stroke. The cyclooxygenase inhibitor aspirin remains the most frequently prescribed antiplatelet drug, followed by adenosine diphosphate P2Y(12) receptor blockers. Glycoprotein IIb-IIIa antagonists are intravenously available antiplatelet agents preventing platelet-to-platelet aggregation via the fibrinogen receptor. The thrombin receptor inhibitor vorapaxar allows the targeting of yet a third pathway of platelet activation. Despite the advent of novel agents and major advances in antiplatelet treatment over the last decade, atherothrombotic events still impair the prognosis of many patients with cardiovascular disease. Consequently, antiplatelet therapy remains a field of intense research and a large number of studies on its various aspects are published each year. This review article summarizes recent developments in antiplatelet therapy in cardiovascular disease focusing particularly on the duration of dual antiplatelet therapy, new treatment regimens, the role of platelet function testing, and potential future targets of antiplatelet agents.
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