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2018 ; 2
(3
): 439-449
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Novel aspects of antiplatelet therapy in cardiovascular disease
#MMPMID30046748
Gremmel T
; Michelson AD
; Frelinger AL III
; Bhatt DL
Res Pract Thromb Haemost
2018[Jul]; 2
(3
): 439-449
PMID30046748
show ga
Antiplatelet therapy is a cornerstone in the secondary prophylaxis of adverse
cardiovascular events such as myocardial infarction and stroke. The
cyclooxygenase inhibitor aspirin remains the most frequently prescribed
antiplatelet drug, followed by adenosine diphosphate P2Y(12) receptor blockers.
Glycoprotein IIb-IIIa antagonists are intravenously available antiplatelet agents
preventing platelet-to-platelet aggregation via the fibrinogen receptor. The
thrombin receptor inhibitor vorapaxar allows the targeting of yet a third pathway
of platelet activation. Despite the advent of novel agents and major advances in
antiplatelet treatment over the last decade, atherothrombotic events still impair
the prognosis of many patients with cardiovascular disease. Consequently,
antiplatelet therapy remains a field of intense research and a large number of
studies on its various aspects are published each year. This review article
summarizes recent developments in antiplatelet therapy in cardiovascular disease
focusing particularly on the duration of dual antiplatelet therapy, new treatment
regimens, the role of platelet function testing, and potential future targets of
antiplatelet agents.