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Novel agents for advanced pancreatic cancer
#MMPMID26369833
Akinleye A
; Iragavarapu C
; Furqan M
; Cang S
; Liu D
Oncotarget
2015[Nov]; 6
(37
): 39521-37
PMID26369833
show ga
Pancreatic cancer is relatively insensitive to conventional chemotherapy.
Therefore, novel agents targeting dysregulated pathways (MAPK/ERK, EGFR, TGF-?,
HEDGEHOG, NOTCH, IGF, PARP, PI3K/AKT, RAS, and Src) are being explored in
clinical trials as monotherapy or in combination with cytotoxic chemotherapy.
This review summarizes the most recent advances with the targeted therapies in
the treatment of patients with advanced pancreatic cancer.
|Antibodies, Monoclonal/*therapeutic use
[MESH]
|Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
[MESH]