Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29099677
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Annu+Rev+Med
2018 ; 69
(ä): 421-436
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Novel Latency Reversal Agents for HIV-1 Cure
#MMPMID29099677
Spivak AM
; Planelles V
Annu Rev Med
2018[Jan]; 69
(ä): 421-436
PMID29099677
show ga
Antiretroviral therapy (ART) has rendered HIV-1 infection a treatable illness;
however, ART is not curative owing to the persistence of replication-competent,
latent proviruses in long-lived resting T cells. Strategies that target these
latently infected cells and allow immune recognition and clearance of this
reservoir will be necessary to eradicate HIV-1 in infected individuals. This
review describes current pharmacologic approaches to reactivate the latent
reservoir so that infected cells can be recognized and targeted, with the
ultimate goal of achieving an HIV-1 cure.
|*Virus Activation
[MESH]
|*Virus Latency
[MESH]
|Acetaldehyde Dehydrogenase Inhibitors/therapeutic use
[MESH]
|Adjuvants, Immunologic/therapeutic use
[MESH]
|Disulfiram/therapeutic use
[MESH]
|HIV Infections/*drug therapy
[MESH]
|HIV-1/*immunology
[MESH]
|Histone Deacetylase Inhibitors/therapeutic use
[MESH]
free
free
free
