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Novel Approaches to Imaging Tumor Metabolism #MMPMID26049695
Tee SS; Keshari KR
Cancer J 2015[May]; 21 (3): 165-73 PMID26049695show ga
The field of metabolism research has made a dramatic resurgence in recent years, fueled by a newfound appreciation of the interactions between metabolites and phenotype. Metabolic substrates and their products can be biomarkers of a wide range of pathologies, including cancer, but our understanding of their in vivo interactions and pathways has been hindered by the robustness of non-invasive imaging approaches. The last 3 decades have been flushed with the development of new techniques for the study of metabolism in vivo. These methods include nuclear based, predominantly positron emission tomography (PET) and magnetic resonance imaging (MRI), many of which have been translated to the clinic. The purpose of this review is to introduce both long standing imaging strategies as well as novel approaches to the study of perturbed metabolic pathways in the setting of carcinogenesis. This will involve descriptions of nuclear probes labeled with 11C and 18F as well 13C for study using hyperpolarized MRI. Highlighting both advantages and disadvantages of each approach, the aim of this summary is to provide the reader with a framework for interrogation of metabolic aberrations in their system of interest.