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10.1146/annurev.pathmechdis.3.121806.154300

http://scihub22266oqcxt.onion/10.1146/annurev.pathmechdis.3.121806.154300
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suck abstract from ncbi


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pmid18039126
      Annu+Rev+Pathol 2008 ; 3 (ä): 587-613
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  • Notch signaling in leukemia #MMPMID18039126
  • Aster JC ; Pear WS ; Blacklow SC
  • Annu Rev Pathol 2008[]; 3 (ä): 587-613 PMID18039126 show ga
  • Recent discoveries indicate that gain-of-function mutations in the Notch1 receptor are very common in human T cell acute lymphoblastic leukemia/lymphoma. This review discusses what these mutations have taught us about normal and pathophysiologic Notch1 signaling, and how these insights may lead to new targeted therapies for patients with this aggressive form of cancer.
  • |Animals [MESH]
  • |Disease Models, Animal [MESH]
  • |Gene Expression Profiling [MESH]
  • |Gene Expression Regulation, Neoplastic [MESH]
  • |Humans [MESH]
  • |Leukemia/genetics/*metabolism [MESH]
  • |Mice [MESH]
  • |Neoplasm Proteins/genetics/*metabolism [MESH]
  • |Receptor, Notch1/genetics/*metabolism [MESH]


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