Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26340640
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26340640
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Biomolecules
2015 ; 5
(3
): 2056-72
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Notable Aspects of Glycan-Protein Interactions
#MMPMID26340640
Cohen M
Biomolecules
2015[Sep]; 5
(3
): 2056-72
PMID26340640
show ga
This mini review highlights several interesting aspects of glycan-mediated
interactions that are common between cells, bacteria, and viruses. Glycans are
ubiquitously found on all living cells, and in the extracellular milieu of
multicellular organisms. They are known to mediate initial binding and
recognition events of both immune cells and pathogens with their target cells or
tissues. The host target tissues are hidden under a layer of secreted
glycosylated decoy targets. In addition, pathogens can utilize and display host
glycans to prevent identification as foreign by the host's immune system
(molecular mimicry). Both the host and pathogens continually evolve. The host
evolves to prevent infection and the pathogens evolve to evade host defenses.
Many pathogens express both glycan-binding proteins and glycosidases.
Interestingly, these proteins are often located at the tip of elongated
protrusions in bacteria, or in the leading edge of the cell. Glycan-protein
interactions have low affinity and, as a result, multivalent interactions are
often required to achieve biologically relevant binding. These enable dynamic
forms of adhesion mechanisms, reviewed here, and include rolling (cells), stick
and roll (bacteria) or surfacing (viruses).
free
free
free
