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2014 ; 30
(6
): 388-92
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Nonsurgical Therapeutic Options in Portal Vein Thrombosis
#MMPMID26288606
Schultheiß M
; Bettinger D
; Thimme R
Viszeralmedizin
2014[Dec]; 30
(6
): 388-92
PMID26288606
show ga
BACKGROUND: Portal vein thrombosis (PVT) is a rare but severe vascular disorder
with an acute and a chronic course. Most patients have underlying liver
cirrhosis; furthermore, thrombophilia is an important risk factor. However,
idiopathic forms are also known. METHODS: This review discusses nonsurgical
treatment options in PVT. RESULTS AND CONCLUSION: Therapy of acute PVT is based
on anticoagulation with heparin that is switched to oral anticoagulants, if
applicable. Catheter-guided invasive therapy should be considered; however,
patients with liver cirrhosis should be screened for portal hypertension before
anticoagulation is mandatory. Therapy of chronic PVT is discussed
controversially; therefore, a strict patient selection and an individual
therapeutic decision are warranted depending on the etiology of PVT. Special
forms of PVT including septic and malignant thrombosis as well as PVT in patients
waiting for liver transplantation require particular therapy algorithms.