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2015 ; 8
(ä): 793
Nephropedia Template TP
gab.com Text
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English Wikipedia
Nonsteroidal antiinflammatory drug induced acute granulomatous interstitial
nephritis
#MMPMID26674186
Jung JH
; Kang KP
; Kim W
; Park SK
; Lee S
BMC Res Notes
2015[Dec]; 8
(ä): 793
PMID26674186
show ga
BACKGROUND: Acute interstitial nephritis is a common cause of acute kidney injury
(AKI). The granulomatous inflammation is rarely but often manifests as a form of
a granulomatous interstitial nephritis (GIN) in the kidney. Acute granulomatous
interstitial nephritis is mainly associated with drugs, infection and autoimmune
diseases. CASE PRESENTATION: A 44-year-old-male visited our out-patient
department with symptoms of nausea, vomiting, and general weakness that had
developed over the previous 2 weeks. He had history of medication, nonsteroidal
anti-inflammatory drugs. On admission to the general ward, his serum creatinine
level was markedly elevated. GIN was confirmed by renal biopsy and 30 mg of
corticosteroid per day was immediately initiated. Subsequently, his serum
creatinine level and uremic symptoms dramatically decreased. CONCLUSION: Acute
granulomatous interstitial nephritis is a rare but important disease on AKI. As
long as we can carefully exclude infectious diseases as the cause of
granulomatous lesion, acute granulomatous interstitial nephritis can be treated
with steroid regardless of the etiologies. Since there is no proven treatment for
the GIN yet, we can carefully suggest that moderate to high dosage corticosteroid
can be helpful for prognosis in case of acute granulomatous interstitial
nephritis of patients with AKI.