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2014 ; 2014
(ä): 436123
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Nonsteroidal anti-inflammatory drugs and prostatic diseases
#MMPMID24900965
Ishiguro H
; Kawahara T
Biomed Res Int
2014[]; 2014
(ä): 436123
PMID24900965
show ga
Prostatic diseases are characterized by increased activity of cytokines, growth
factors, and cyclooxygenases- (COX-) 1 and 2. Activation of COX-1 and COX-2
results in increased levels of prostaglandins and the induction of angiogenic,
antiapoptotic and inflammatory processes. Inhibition of COX enzymes by members of
the widely used nonsteroidal anti-inflammatory drug (NSAID) class of drugs
decreases prostaglandin production, and exerts a variety of anti-inflammatory,
antipyretic, and antinociceptive effects. While numerous in vitro, in vivo, and
clinical studies have shown that NSAIDs inhibit the risk and progression of
prostatic diseases, the relationship between NSAIDs and such diseases remains
controversial. Here we review the literature in this area, critically analyzing
the benefits and caveats associated with the use of NSAIDs in the treatment of
prostatic diseases.
|Animals
[MESH]
|Anti-Inflammatory Agents, Non-Steroidal/*pharmacology/*therapeutic use
[MESH]