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Noninvasive imaging of peripheral nerves
#MMPMID25766202
Rangavajla G
; Mokarram N
; Masoodzadehgan N
; Pai SB
; Bellamkonda RV
Cells Tissues Organs
2014[]; 200
(1
): 69-77
PMID25766202
show ga
Recent developments in the field of peripheral nerve imaging extend the
capabilities of imaging modalities to assist in the diagnosis and treatment of
patients with peripheral nerve maladies. Methods such as magnetic resonance
imaging (MRI) and its derivative diffusion tensor imaging (DTI), ultrasound (US)
and positron emission tomography (PET) are capable of assessing nerve structure
and function following injury and relating the state of the nerve to
electrophysiological and histological analysis. Of the imaging methods surveyed
here, each offered unique and interesting advantages related to the field. MRI
offered the opportunity to visualize immune activity on the injured nerve
throughout the course of the regeneration process, and DTI offered numerical
characterization of the injury and the ability to develop statistical bases for
diagnosing injury. US extends imaging to the treatment phase by enabling more
precise analgesic applications following surgery, and PET represents a novel
method of assessing nerve injury through analysis of relative metabolism rates in
injured and healthy tissue. Exciting new possibilities to enhance and extend the
abilities of imaging methods are also discussed, including innovative contrast
agents, some of which enable multimodal imaging approaches and present
opportunities for treatment application.