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2017 ; 28
(2
): 122-133
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Nonconventional Markers of Sepsis
#MMPMID28757820
Kustán P
; Horváth-Szalai Z
; Mühl D
EJIFCC
2017[May]; 28
(2
): 122-133
PMID28757820
show ga
Sepsis still remains a challenging healthcare problem with high mortality rate.
To improve outcome, early diagnosis and monitoring of sepsis is of utmost
importance. In this process objective laboratory parameters are the most helpful.
Procalcitonin and C-reactive protein are the most commonly used and recommended
markers of sepsis however, more than 200 sepsis biomarkers have already been
published. This mini review focuses on nonconventional novel possibilities for
the recognition of sepsis severity. Presepsin, actin and actin scavenger proteins
(gelsolin and Gc-globulin) and orosomucoid are discussed. Besides serum
parameters, the urinary levels of these markers are also elaborated, since
urinary biomarkers of sepsis provide new diagnostic implications and are helpful
for monitoring both the kidney function and the septic process. Increasing serum
actin levels and decreasing levels of actin binding proteins seem to be
associated with sepsis severity and outcome. Actin can be detected in the urine
samples of septic patients as well, and strongly elevated levels of it were found
in sepsis-related acute kidney injury. Both serum and urinary orosomucoid might
be able to indicate sepsis, however urinary orosomucoid is a more sensitive
inflammatory marker. Novel laboratory tests can provide rapid help for clinical
decision making because the key point in successful treatment lies in the early
diagnosis of sepsis.
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