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2015 ; 15
(ä): 7
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Noncompaction cardiomyopathy: a substrate for a thromboembolic event
#MMPMID25618133
Tavares de Melo MD
; de Araújo Filho JA
; Parga Filho JR
; de Lima CR
; Mady C
; Kalil-Filho R
; Salemi VM
BMC Cardiovasc Disord
2015[Jan]; 15
(ä): 7
PMID25618133
show ga
BACKGROUND: Noncompaction cardiomyopathy (NCC) is a rare genetic cardiomyopathy
characterized by a thin, compacted epicardial layer and an extensive noncompacted
endocardial layer. The clinical manifestations of this disease include
ventricular arrhythmia, heart failure, and systemic thromboembolism. CASE
PRESENTATION: A 43-year-old male was anticoagulated by pulmonary thromboembolism
for 1 year when he developed progressive dyspnea. Cardiovascular magnetic
resonance imaging showed severe biventricular trabeculation with an ejection
fraction of 15%, ratio of maximum noncompacted/compacted diastolic myocardial
thickness of 3.2 and the presence of exuberant biventricular apical thrombus.
CONCLUSION: Still under discussion is the issue of which patients and when they
should be anticoagulated. It is generally recommended to those presenting
ventricular systolic dysfunction, antecedent of systemic embolism, presence of
cardiac thrombus and atrial fibrillation. In clinical practice the patients with
NCC and ventricular dysfunction have been given oral anticoagulation, although
there are no clinical trials showing the real safety and benefit of this
treatment.
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