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2014 ; 5
(6
): 835-47
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Noncoding RNAs and the borders of heterochromatin
#MMPMID25044367
Cohen AL
; Jia S
Wiley Interdiscip Rev RNA
2014[Nov]; 5
(6
): 835-47
PMID25044367
show ga
Eukaryotic genomes contain long stretches of repetitive DNA sequences, which are
the preferred sites for the assembly of heterochromatin structures. The formation
of heterochromatin results in highly condensed chromosomal domains that limit the
accessibility of DNA to the transcription and recombination machinery to maintain
genome stability. Heterochromatin has the tendency to spread, and the formation
of boundaries that block heterochromatin spreading is required to maintain stable
gene expression patterns. Recent work has suggested that noncoding RNAs (ncRNAs)
are involved in regulating boundary formation in addition to their
well-established roles in chromatin regulation. Here, we present a review of our
current understanding of the involvement of ncRNA at the boundaries of
heterochromatin, highlighting their mechanisms of action in different settings.
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