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2015 ; 6
(6
): 615-29
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Noncoding RNA control of cellular senescence
#MMPMID26331977
Abdelmohsen K
; Gorospe M
Wiley Interdiscip Rev RNA
2015[Nov]; 6
(6
): 615-29
PMID26331977
show ga
Senescent cells accumulate in normal tissues with advancing age and arise by
long-term culture of primary cells. Senescence develops following exposure to a
range of stress-causing agents and broadly influences the physiology and
pathology of tissues, organs, and systems in the body. While many proteins are
known to control senescence, numerous noncoding (nc)RNAs are also found to
promote or repress the senescent phenotype. Here, we review the regulatory ncRNAs
(primarily microRNAs and lncRNAs) identified to-date as key modulators of
senescence. We highlight the major senescent pathways (p53/p21 and pRB/p16), as
well as the senescence-associated secretory phenotype (SASP) and other
senescence-associated events governed by ncRNAs, and discuss the importance of
understanding comprehensively the ncRNAs implicated in cell senescence.
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