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10.3390/biomedicines6020066

http://scihub22266oqcxt.onion/10.3390/biomedicines6020066
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suck abstract from ncbi


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pmid29874793
      Biomedicines 2018 ; 6 (2 ): ä
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  • Noncanonical NF-?B in Cancer #MMPMID29874793
  • Tegowski M ; Baldwin A
  • Biomedicines 2018[Jun]; 6 (2 ): ä PMID29874793 show ga
  • The NF-?B pathway is a critical regulator of immune responses and is often dysregulated in cancer. Two NF-?B pathways have been described to mediate these responses, the canonical and the noncanonical. While understudied compared to the canonical NF-?B pathway, noncanonical NF-?B and its components have been shown to have effects, usually protumorigenic, in many different cancer types. Here, we review noncanonical NF-?B pathways and discuss its important roles in promoting cancer. We also discuss alternative NF-?B-independent functions of some the components of noncanonical NF-?B signaling. Finally, we discuss important crosstalk between canonical and noncanonical signaling, which blurs the two pathways, indicating that understanding the full picture of NF-?B regulation is critical to deciphering how this broad pathway promotes oncogenesis.
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