Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26556987
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26556987
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 World+J+Gastroenterol
2015 ; 21
(41
): 11567-83
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Non-invasive diagnosis of liver fibrosis and cirrhosis
#MMPMID26556987
Lurie Y
; Webb M
; Cytter-Kuint R
; Shteingart S
; Lederkremer GZ
World J Gastroenterol
2015[Nov]; 21
(41
): 11567-83
PMID26556987
show ga
The evaluation and follow up of liver fibrosis and cirrhosis have been
traditionally performed by liver biopsy. However, during the last 20 years, it
has become evident that this "gold-standard" is imperfect; even according to its
proponents, it is only "the best" among available methods. Attempts at uncovering
non-invasive diagnostic tools have yielded multiple scores, formulae, and imaging
modalities. All are better tolerated, safer, more acceptable to the patient, and
can be repeated essentially as often as required. Most are much less expensive
than liver biopsy. Consequently, their use is growing, and in some countries the
number of biopsies performed, at least for routine evaluation of hepatitis B and
C, has declined sharply. However, the accuracy and diagnostic value of most, if
not all, of these methods remains controversial. In this review for the
practicing physician, we analyze established and novel biomarkers and physical
techniques. We may be witnessing in recent years the beginning of the end of the
first phase for the development of non-invasive markers. Early evidence suggests
that they might be at least as good as liver biopsy. Novel experimental markers
and imaging techniques could produce a dramatic change in diagnosis in the near
future.