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2017 ; 10
(1
): 99
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Non-driver mutations in myeloproliferative neoplasm-associated myelofibrosis
#MMPMID28464892
Li B
; Gale RP
; Xu Z
; Qin T
; Song Z
; Zhang P
; Bai J
; Zhang L
; Zhang Y
; Liu J
; Huang G
; Xiao Z
J Hematol Oncol
2017[May]; 10
(1
): 99
PMID28464892
show ga
We studied non-driver mutations in 62 subjects with myeloproliferative neoplasm
(MPN)-associated myelofibrosis upon diagnosis, including 45 subjects with primary
myelofibrosis (PMF) and 17 with post-polycythemia vera or post-essential
thrombocythemia myelofibrosis (post-PV/ET MF). Fifty-eight subjects had ?1
non-driver mutation upon diagnosis. Mutations in mRNA splicing genes, especially
in U2AF1, were significantly more frequent in PMF than in post-PV/ET MF (33 vs.
6%; P?=?0.015). There were also striking differences in clonal architecture.
These data indicate different genomic spectrums between PMF and post-PV/ET MF.
|*Mutation
[MESH]
|Adult
[MESH]
|Aged
[MESH]
|Aged, 80 and over
[MESH]
|Apoptosis/genetics
[MESH]
|Cell Adhesion/genetics
[MESH]
|Cell Cycle/genetics
[MESH]
|Chromatin Assembly and Disassembly/genetics
[MESH]