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10.1186/s13045-017-0472-5

http://scihub22266oqcxt.onion/10.1186/s13045-017-0472-5
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suck abstract from ncbi


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pmid28464892
      J+Hematol+Oncol 2017 ; 10 (1 ): 99
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  • Non-driver mutations in myeloproliferative neoplasm-associated myelofibrosis #MMPMID28464892
  • Li B ; Gale RP ; Xu Z ; Qin T ; Song Z ; Zhang P ; Bai J ; Zhang L ; Zhang Y ; Liu J ; Huang G ; Xiao Z
  • J Hematol Oncol 2017[May]; 10 (1 ): 99 PMID28464892 show ga
  • We studied non-driver mutations in 62 subjects with myeloproliferative neoplasm (MPN)-associated myelofibrosis upon diagnosis, including 45 subjects with primary myelofibrosis (PMF) and 17 with post-polycythemia vera or post-essential thrombocythemia myelofibrosis (post-PV/ET MF). Fifty-eight subjects had ?1 non-driver mutation upon diagnosis. Mutations in mRNA splicing genes, especially in U2AF1, were significantly more frequent in PMF than in post-PV/ET MF (33 vs. 6%; P?=?0.015). There were also striking differences in clonal architecture. These data indicate different genomic spectrums between PMF and post-PV/ET MF.
  • |*Mutation [MESH]
  • |Adult [MESH]
  • |Aged [MESH]
  • |Aged, 80 and over [MESH]
  • |Apoptosis/genetics [MESH]
  • |Cell Adhesion/genetics [MESH]
  • |Cell Cycle/genetics [MESH]
  • |Chromatin Assembly and Disassembly/genetics [MESH]
  • |Clone Cells [MESH]
  • |DNA Methylation/genetics [MESH]
  • |DNA Repair/genetics [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Polycythemia Vera/complications/*genetics [MESH]
  • |Primary Myelofibrosis/etiology/*genetics [MESH]
  • |RNA Splicing/genetics [MESH]
  • |Signal Transduction/genetics [MESH]
  • |Splicing Factor U2AF/genetics [MESH]
  • |Thrombocythemia, Essential/complications/genetics [MESH]


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