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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Biochem
2015 ; 158
(5
): 355-65
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Non-canonical WNT signalling in the lung
#MMPMID26261051
Li C
; Bellusci S
; Borok Z
; Minoo P
J Biochem
2015[Nov]; 158
(5
): 355-65
PMID26261051
show ga
The role of WNT signalling in metazoan organogenesis has been a topic of
widespread interest. In the lung, while the role of canonical WNT signalling has
been examined in some detail by multiple studies, the non-canonical WNT
signalling has received limited attention. Reliable evidence shows that this
important signalling mechanism constitutes a major regulatory pathway in lung
development. In addition, accumulating evidence has also shown that the
non-canonical WNT pathway is critical for maintaining lung homeostasis and that
aberrant activation of this pathway may underlie several debilitating lung
diseases. Functional analyses have further revealed that the non-canonical WNT
pathway regulates multiple cellular activities in the lung that are dependent on
the specific cellular context. In most cell types, non-canonical WNT signalling
regulates canonical WNT activity, which is also critical for many aspects of lung
biology. This review will summarize what is currently known about the role of
non-canonical WNT signalling in lung development, homeostasis and pathogenesis of
disease.
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