Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28253332
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28253332
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 PLoS+Pathog
2017 ; 13
(3
): e1006177
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Nod2: The intestinal gate keeper
#MMPMID28253332
Al Nabhani Z
; Dietrich G
; Hugot JP
; Barreau F
PLoS Pathog
2017[Mar]; 13
(3
): e1006177
PMID28253332
show ga
Nucleotide-binding oligomerization domain 2 (NOD2) is an intracellular pattern
recognition receptor that senses bacterial peptidoglycan (PGN)-conserved motifs
in cytosol and stimulates host immune response. The association of NOD2 mutations
with a number of inflammatory pathologies, including Crohn disease (CD),
Graft-versus-host disease (GVHD), and Blau syndrome, highlights its pivotal role
in host-pathogen interactions and inflammatory response. Stimulation of NOD2 by
its ligand (muramyl dipeptide) activates pro-inflammatory pathways such as
nuclear factor-?B (NF-?B), mitogen-activated protein kinases (MAPKs), and
Caspase-1. A loss of NOD2 function may result in a failure in the control of
microbial infection, thereby initiating systemic responses and aberrant
inflammation. Because the ligand of Nod2 is conserved in both gram-positive and
gram-negative bacteria, NOD2 detects a wide variety of microorganisms.
Furthermore, current literature evidences that NOD2 is also able to control
viruses' and parasites' infections. In this review, we present and discuss recent
developments about the role of NOD2 in shaping the gut commensal microbiota and
pathogens, including bacteria, viruses, and parasites, and the mechanisms by
which Nod2 mutations participate in disease occurrence.
free
free
free
