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2014 ; 353
(1
): 1-7
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Nitric oxide in cancer metastasis
#MMPMID25079686
Cheng H
; Wang L
; Mollica M
; Re AT
; Wu S
; Zuo L
Cancer Lett
2014[Oct]; 353
(1
): 1-7
PMID25079686
show ga
Cancer metastasis is the spread and growth of tumor cells from the original
neoplasm to further organs. This review analyzes the role of nitric oxide (NO), a
signaling molecule, in the regulation of cancer formation, progression, and
metastasis. The action of NO on cancer relies on multiple factors including cell
type, metastasis stage, and organs involved. Various chemotherapy drugs cause
cells to release NO, which in turn induces cytotoxic death of breast, liver, and
skin tumors. However, NO has also been clinically connected to a poor cancer
prognosis because of its role in angiogenesis and intravasation. This supports
the claim that NO can be characterized as both pro-metastatic and
anti-metastatic, depending on specific factors. The inhibition of cell
proliferation and anti-apoptosis pathways by NO donors has been proposed as a
novel therapy to various cancers. Studies suggest that NO-releasing non-steroidal
anti-inflammatory drugs act on cancer cells in several ways that may make them
ideal for cancer therapy. This review summarizes the biological significance of
NO in each step of cancer metastasis, its controversial effects for cancer
progression, and its therapeutic potential.
|*Signal Transduction/drug effects
[MESH]
|Animals
[MESH]
|Anti-Inflammatory Agents, Non-Steroidal/therapeutic use
[MESH]
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