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2017 ; 2017
(2
): 14
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Nitric oxide and pulmonary arterial hypertension
#MMPMID29644226
Chester AH
; Yacoub MH
; Moncada S
Glob Cardiol Sci Pract
2017[Jun]; 2017
(2
): 14
PMID29644226
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The pathogenesis of pulmonary arterial hypertension remains undefined. Changes in
the expression and effects mediated by a number of vasoactive factors have been
implicated to play a role in the onset and progression of the disease. The source
of many of these mediators, such as nitric oxide (NO), prostacyclin and
endothelin-1 (ET-1), is the pulmonary endothelium. This article focus in the role
of nitric oxide in PAH, reviewing the evidence for its involvement in regulation
of pulmonary a vascular tone under physiological conditions, the mechanisms by
which it can contribute to the pathological changes seen in PAH and strategies
for the use of NO as a therapy for treatment of the disease.
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