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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Leukoc+Biol
2016 ; 100
(5
): 1105-1112
Nephropedia Template TP
J Leukoc Biol
2016[Nov]; 100
(5
): 1105-1112
PMID27312847
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NETs serve to ensnare and kill microbial pathogens. However, NETs can at the same
time contribute to tissue damage and excessive inflammation. Nicotine is a major
toxic agent and has been associated with exacerbated inflammatory diseases. The
current study aimed at investigating the role of nicotine, the addictive
component of tobacco and electronic cigarettes, on triggering NET formation. We
report that nicotine induces neutrophils to release NETs in a dose-dependent
manner. Nicotine-induced NET formation is mediated via nicotine acetylcholine
receptors, depends on Akt and PAD4 activation, but is Nox2-independent, as
demonstrated by pharmacological inhibition of Nox2 and by use of Nox2-deficient
mouse neutrophils. These findings demonstrate that nicotine induces NETs, which
may in turn contribute to smoking-related diseases.
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