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2016 ; 10
(3
): 425-35
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Nicotine Replacement Therapy: An Overview
#MMPMID27610066
Wadgave U
; Nagesh L
Int J Health Sci (Qassim)
2016[Jul]; 10
(3
): 425-35
PMID27610066
show ga
Today tobacco use is the single greatest preventable cause of death in the world.
Tobacco use is often incorrectly perceived to be solely a personal choice. This
is contradicted by the fact that when fully aware of the health impact, most
tobacco users want to quit but find it difficult to stop due to the addictiveness
of nicotine. Henceforth, Nicotine replacement therapy (NRT) came into existence
which temporarily replaces much of the nicotine from tobacco to reduce motivation
to consume tobacco and nicotine withdrawal symptoms, thus easing the transition
from cigarette smoking to complete abstinence. Various alternative nicotine
sources (gum, transdermal patch, nasal spray, inhaler and sublingual
tablets/lozenges) have been incorporated into tobacco cessation programs. Recent
research is more focusing on rapid delivery of nicotine (Nicotine preloading,
true pulmonary inhaler) and immunological approaches (nicotine vaccine) to tackle
nicotine dependence. These NRTs are in general well tolerated and have minimal
adverse effects. The review aims to summarize literature on various modes of
nicotine replacement therapy methods currently used to treat nicotine dependence,
and to give an overview about future possible approaches to treat tobacco use
disorder.
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