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10.1055/s-0036-1571343 http://scihub22266oqcxt.onion/10.1055/s-0036-1571343 C5680043!5680043 !27056150     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27056150 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Semin+Thromb+Hemost 2016 ; 42 (4 ): 445-54 Nephropedia Template TP {{tp|p=27056150 |t=2016. Newly-Recognized Roles of Factor XIII in Thrombosis |pdf=|usr=}}{{27056150 }} gab.com Text Newly-Recognized Roles of Factor XIII in Thrombosis JO: Semin Thromb Hemost http://www.kidney.de/pget.php?&tw=1&pmid=27056150 #FOAvip Arterial and venous thromboses are major contributors to coagulation-associated morbidity and mortality. Greater understanding of mechanisms leading to thrombus formation and stability is expected to lead to improved treatment strategies. Factor XIII (FXIII) is a transglutaminase found in plasma and platelets. During thrombosis, activated FXIII cross-links fibrin and promotes thrombus stability. Recent studies have provided new information about FXIII activity during coagulation and its effects on clot composition and function. These findings reveal newly-recognized roles for FXIII in thrombosis. Herein, we review published literature on FXIII biology and effects on fibrin structure and stability, epidemiologic data associating FXIII with thrombosis, and evidence from animal models indicating FXIII has an essential role in determining thrombus stability, composition, and size. Twit Text FOAVip Newly-Recognized Roles of Factor XIII in Thrombosis ????Semin Thromb Hemost http://www.kidney.de/pget.php?&tw=1&pmid=27056150 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27056150 #FOAvip English Wikipedia <ref>{{Cite pmid|27056150 }}</ref> Newly-Recognized Roles of Factor XIII in Thrombosis #MMPMID27056150 Byrnes JR ; Wolberg AS Semin Thromb Hemost 2016[Jun]; 42 (4 ): 445-54 PMID27056150 show ga Arterial and venous thromboses are major contributors to coagulation-associated morbidity and mortality. Greater understanding of mechanisms leading to thrombus formation and stability is expected to lead to improved treatment strategies. Factor XIII (FXIII) is a transglutaminase found in plasma and platelets. During thrombosis, activated FXIII cross-links fibrin and promotes thrombus stability. Recent studies have provided new information about FXIII activity during coagulation and its effects on clot composition and function. These findings reveal newly-recognized roles for FXIII in thrombosis. Herein, we review published literature on FXIII biology and effects on fibrin structure and stability, epidemiologic data associating FXIII with thrombosis, and evidence from animal models indicating FXIII has an essential role in determining thrombus stability, composition, and size. |*Blood Coagulation [MESH] |Animals [MESH] |Blood Platelets/enzymology [MESH] |Factor XIII/*metabolism [MESH] |Fibrin/*metabolism [MESH] |Humans [MESH] |Transglutaminases/blood [MESH]Newly-Recognized Roles of Factor XIII in Thrombosis (epmc).pdf DeepDyve Pubget Overpricing