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10.3748/wjg.v22.i15.3892 http://scihub22266oqcxt.onion/10.3748/wjg.v22.i15.3892 C4823241!4823241 !27099434     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27099434 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27099434 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       World+J+Gastroenterol 2016 ; 22 (15 ): 3892-906 Nephropedia Template TP {{tp|p=27099434 |t=2016. New treatment options for alcoholic hepatitis |pdf=|usr=}}{{27099434 }} gab.com Text New treatment options for alcoholic hepatitis JO: World J Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=27099434 #FOAvip The burden of alcoholic liver disease has rapidly grown in the past two decades and is expected to increase further in the coming years. Alcoholic hepatitis, the most florid presentation of alcoholic liver disease, continues to have high morbidity and mortality, with significant financial and healthcare burden with limited treatment options. Steroids remain the current standard of care in severe alcoholic hepatitis in carefully selected patients. No specific treatments are available for those patients who are steroid ineligible, intolerant or unresponsive. Liver transplant has shown good short-term outcome; however, feasibility, ethical and economic concerns remain. Modification of gut microbiota composition and their products, such as lipopolysaccharide, nutritional interventions, immune modulation, increasing steroid sensitivity, genetic polymorphism and epigenetic modification of alcohol induced liver damage, augmenting hepatic regeneration using GCSF are potential therapeutic avenues in steroid non-responsive/ineligible patients. With better understanding of the pathophysiology, using "Omics" platforms, newer options for patients with alcoholic hepatitis are expected soon. Twit Text FOAVip New treatment options for alcoholic hepatitis ????World J Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=27099434 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27099434 #FOAvip English Wikipedia <ref>{{Cite pmid|27099434 }}</ref> New treatment options for alcoholic hepatitis #MMPMID27099434 Shasthry SM ; Sarin SK World J Gastroenterol 2016[Apr]; 22 (15 ): 3892-906 PMID27099434 show ga The burden of alcoholic liver disease has rapidly grown in the past two decades and is expected to increase further in the coming years. Alcoholic hepatitis, the most florid presentation of alcoholic liver disease, continues to have high morbidity and mortality, with significant financial and healthcare burden with limited treatment options. Steroids remain the current standard of care in severe alcoholic hepatitis in carefully selected patients. No specific treatments are available for those patients who are steroid ineligible, intolerant or unresponsive. Liver transplant has shown good short-term outcome; however, feasibility, ethical and economic concerns remain. Modification of gut microbiota composition and their products, such as lipopolysaccharide, nutritional interventions, immune modulation, increasing steroid sensitivity, genetic polymorphism and epigenetic modification of alcohol induced liver damage, augmenting hepatic regeneration using GCSF are potential therapeutic avenues in steroid non-responsive/ineligible patients. With better understanding of the pathophysiology, using "Omics" platforms, newer options for patients with alcoholic hepatitis are expected soon. |Anti-Bacterial Agents/therapeutic use [MESH] |Anti-Inflammatory Agents/adverse effects/*therapeutic use [MESH] |Drug Resistance [MESH] |Gastrointestinal Microbiome [MESH] |Gastrointestinal Tract/microbiology [MESH] |Genetic Therapy [MESH] |Hepatitis, Alcoholic/genetics/immunology/microbiology/*therapy [MESH] |Humans [MESH] |Liver Transplantation [MESH] |Nutritional Support [MESH] |Pentoxifylline/adverse effects/*therapeutic use [MESH] |Prebiotics [MESH] |Probiotics [MESH] |Steroids/adverse effects/*therapeutic use [MESH]New treatment options for alcoholic hepatitis (epmc).pdf DeepDyve Pubget Overpricing