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2017 ; 9
(5
): 793-803
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New perspectives in nanotherapeutics for chronic respiratory diseases
#MMPMID28914424
da Silva AL
; Cruz FF
; Rocco PRM
; Morales MM
Biophys Rev
2017[Oct]; 9
(5
): 793-803
PMID28914424
show ga
According to the World Health Organization (WHO), hundreds of millions of people
of all ages and in all countries suffer from chronic respiratory diseases, with
particular negative consequences such as poor health-related quality of life,
impaired work productivity, and limitations in the activities of daily living.
Chronic obstructive pulmonary disease, asthma, occupational lung diseases (such
as silicosis), cystic fibrosis, and pulmonary arterial hypertension are the most
common of these diseases, and none of them are curable with current therapies.
The advent of nanotechnology holds great therapeutic promise for respiratory
conditions, because non-viral vectors are able to overcome the mucus and lung
remodeling barriers, increasing pharmacologic and therapeutic potency. It has
been demonstrated that the extent of pulmonary nanoparticle uptake depends not
only on the physical and chemical features of nanoparticles themselves, but also
on the health status of the organism; thus, the huge diversity in nanotechnology
could revolutionize medicine, but safety assessment is a challenging task. Within
this context, the present review discusses some of the major new perspectives in
nanotherapeutics for lung disease and highlights some of the most recent studies
in the field.