10.1002/jrsm.1191 http://scihub22266oqcxt.onion/10.1002/jrsm.1191 C4964911!4964911
!26610739
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Res+Synth+Methods
2016 ; 7
(3
): 314-28
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New models for describing outliers in meta-analysis
#MMPMID26610739
Baker R
; Jackson D
Res Synth Methods
2016[Sep]; 7
(3
): 314-28
PMID26610739
show ga
An unobserved random effect is often used to describe the between-study variation
that is apparent in meta-analysis datasets. A normally distributed random effect
is conventionally used for this purpose. When outliers or other unusual estimates
are included in the analysis, the use of alternative random effect distributions
has previously been proposed. Instead of adopting the usual hierarchical approach
to modelling between-study variation, and so directly modelling the study
specific true underling effects, we propose two new marginal distributions for
modelling heterogeneous datasets. These two distributions are suggested because
numerical integration is not needed to evaluate the likelihood. This makes the
computation required when fitting our models much more robust. The properties of
the new distributions are described, and the methodology is exemplified by
fitting models to four datasets. © 2015 The Authors. Research Synthesis Methods
published by John Wiley & Sons, Ltd.
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