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2010 ; ä (198
): 3-27
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New insights into ovarian function
#MMPMID20839083
Richards JS
; Pangas SA
Handb Exp Pharmacol
2010[]; ä (198
): 3-27
PMID20839083
show ga
Infertility adversely affects many couples worldwide. Conversely, the exponential
increase in world population threatens our planet and its resources. Therefore, a
greater understanding of the fundamental cellular and molecular events that
control the size of the primordial follicle pool and follicular development is of
utmost importance to develop improved in vitro fertilization as well as to design
novel approaches to regulate fertility. In this review we attempt to highlight
some new advances in basic research of the mammalian ovary that have occurred in
recent years focusing primarily on mouse models that have contributed to our
understanding of ovarian follicle formation, development, and ovulation. We hope
that these new insights into ovarian function will trigger more research and
translation to clinically relevant problems.