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10.12703/P7-48 http://scihub22266oqcxt.onion/10.12703/P7-48 C4447046!4447046 !26097721     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26097721 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       F1000Prime+Rep 2015 ; 7 (ä): 48 Nephropedia Template TP {{tp|p=26097721 |t=2015. New insights into nucleolar structure and function |pdf=|usr=}}{{26097721 }} gab.com Text New insights into nucleolar structure and function JO: F1000Prime Rep http://www.kidney.de/pget.php?&tw=1&pmid=26097721 #FOAvip The nucleolus is a non-membrane-bound nuclear organelle found in all eukaryotes. It is the quintessential 'RNA-seeded' nuclear body, forming around specific chromosomal features called nucleolar organizing regions that contain arrays of ribosomal DNA. Assembly is triggered by activation of RNA polymerase I-mediated transcription and regulated in mammalian cells in a cell cycle-dependent manner. Although the nucleolus is best known for its role in coordinating ribosome biogenesis, biochemical and proteomic analyses have revealed a much wider functional complexity than previously appreciated, including roles in cell cycle regulation, DNA damage sensing and repair, pre-mRNA processing, telomere metabolism, processing of non-coding RNAs, and coordination of the cellular response to various stresses. Despite these advances, much remains to be learned about the full range of biological processes that occur within, or involve, this organelle and how its assembly/disassembly and functional reorganization in response to various stimuli are regulated. Here, we review the impact of recent studies that provide major insights into these fundamental questions, and we highlight the therapeutic potential of targeting nucleolar pathways. Twit Text FOAVip New insights into nucleolar structure and function ????F1000Prime Rep http://www.kidney.de/pget.php?&tw=1&pmid=26097721 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26097721 #FOAvip English Wikipedia <ref>{{Cite pmid|26097721 }}</ref> New insights into nucleolar structure and function #MMPMID26097721 Lam YW ; Trinkle-Mulcahy L F1000Prime Rep 2015[]; 7 (ä): 48 PMID26097721 show ga The nucleolus is a non-membrane-bound nuclear organelle found in all eukaryotes. It is the quintessential 'RNA-seeded' nuclear body, forming around specific chromosomal features called nucleolar organizing regions that contain arrays of ribosomal DNA. Assembly is triggered by activation of RNA polymerase I-mediated transcription and regulated in mammalian cells in a cell cycle-dependent manner. Although the nucleolus is best known for its role in coordinating ribosome biogenesis, biochemical and proteomic analyses have revealed a much wider functional complexity than previously appreciated, including roles in cell cycle regulation, DNA damage sensing and repair, pre-mRNA processing, telomere metabolism, processing of non-coding RNAs, and coordination of the cellular response to various stresses. Despite these advances, much remains to be learned about the full range of biological processes that occur within, or involve, this organelle and how its assembly/disassembly and functional reorganization in response to various stimuli are regulated. Here, we review the impact of recent studies that provide major insights into these fundamental questions, and we highlight the therapeutic potential of targeting nucleolar pathways. äNew insights into nucleolar structure and function (epmc).pdf DeepDyve Pubget Overpricing