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2015 ; 21
(3
): 154-63
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New insights into gastrointestinal anthrax infection
#MMPMID25577136
Owen JL
; Yang T
; Mohamadzadeh M
Trends Mol Med
2015[Mar]; 21
(3
): 154-63
PMID25577136
show ga
Bacterial infections are the primary cause of gastrointestinal (GI) disorders in
both developing and developed countries, and are particularly dangerous for
infants and children. Bacillus anthracis is the 'archetype zoonotic' pathogen; no
other infectious disease affects such a broad range of species, including humans.
Importantly, there are more case reports of GI anthrax infection in children than
inhalational disease. Early diagnosis is difficult and widespread systemic
disease develops rapidly. This review highlights new findings concerning the
roles of the gut epithelia, commensal microbiota, and innate lymphoid cells
(ILCs) in initiation of disease and systemic dissemination in animal models of GI
anthrax, the understanding of which is crucial to designing alternative therapies
that target the establishment of infection.